… in PDA tumorigenesis and P21-activated kinases (PAKs) are … Priming and activation of
antigen-presenting cells (APC) and … T cell depletion did not affect tumour growth in a PDA mouse …

… investigated by using gene knockout mouse models, with the … that PAK1 inhibition impeded
carcinogenesis in several … targeting PAK1 inhibition and cell cycle destruction would reap …

… The p21 Activated Kinases (PAKs) are serine threonine kinases and play important … Depletion
of PAK1 enhanced the immune system and inhibited intestinal tumorigenesis in a mouse …

… on embryonic development and various cellular activities [14]. ATRA exerts these effects by
… immune system activation to inhibit intestinal tumorigenesis in a mouse model of intestinal …

… In endothelial cells, depletion of PAK2 in adult mice … -7 reduced PAK1 levels and inhibited
tumorigenic potential [37]. … in the anti-tumor immune response has recently been reported by …

… The threonine/serine kinase P21-activated kinase 1 (PAK1) … to skin carcinogenesis, we
generated F 1 mice by crossing a … depletion of epidermal stem cells, thereby inhibiting tumors. …

… active in cells and mice, and while some inhibitors have entered … PAK1 with the immune
response to intestinal tumors [170]. … to inhibit PCa by phosphorylating the AR and tumorigenic E3 …

… also be inhibited as a result of inhibiting the kinase activity of … In APC∆14/+ mice, depletion
of PAK1 results in the increase of … , revealing its role in the immune response to tumors [72]. …

… arrest, and the inhibition of p21-activated kinase 1 (PAK1), a … [50] induced pulmonary
carcinogenesis in male ddY mice by … roles in the destruction of tissues and in inflammatory bowel …

… interactions between Apc and Smad4 in the intestine, we 9 … disruption of the β-catenin
destruction complex by LOF of 15 … Mice were moni- 14 tored daily, small intestinal and colonic …